Jessica Kingsley
Research Associate 2018-2021
Research Projects:
"Metabolic Fluctuations in Cancer"
topic: to develop mathematical models for analysing causes and consequences of short-time metabolic fluctuations in cancer tissue
Manuscript "Bridging cell-scale simulations and radiologic images to explain short-time intratumoral oxygen fluctuations" published in PLoS Computational Biology 17(7):e1009206, doi: 10.1371/journal.pcbi.1009206; authors: Jessica Kingsley, Jimmy Costello, Natarajan Raghunand, and Kasia Rejniak, link to the article
a representative final simulation showing oxygen fluctuation within a tissue (left) and fitting to the average pO2 data recorded experimentally (rigth).
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| black ROI | blue ROI | red ROI | magenta ROI |
fast oxygen fluctuations within four regions of interest (ROIs) with tissue morphologies shown in the top row; O2 fluctuations are caused by either changes in vascular oxygen influx (second row) or modifications in oxygen absorption by tumor cells (third row); pO2 fluctuations recorded experimentally are shown in the bottom row for each ROI.
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a simulation showing stabilisation of oxygen gradient for a given tissue resulting from constant influx of oxygen from the vasculture and constant uptake of oxygen by both tumor and stromal cells: (left) oxygen gradient within the tissue; (right) oxygen level averaged over the whole tissue area.
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Cancer Biology & Evolution Annual Symposium, October 14th, 2019, presented poster "Medical imaging-based in silico reconstruction of tumor microenvironment" in collaboration with Natarajan Raghunand (Cancer Physiology) and Marilyn Bui (Microscopy).